The glucocorticoid receptor (GR) is an important anti-cancer target in lymphoid cancers but has been understudied in solid tumors like lung cancer, although glucocorticoids are often given with chemotherapy regimens to mitigate side effects.Here, we identify a dexamethasone-GR mediated anti-cancer response in a subset of aggressive non-small cell l
DNA replication is initiated upon binding of "initiators" to origins of replication.In simian virus 40 (SV40), the core origin contains four pentanucleotide binding sites organized as pairs of inverted repeats.Here we describe the nightstick twm-850xl crystal structures of the origin binding domain (obd) of the SV40 large T-antigen (T-ag) both with
ObjectiveThis study contributes to the literature by empirically testing the extent to which place-based structural racism is a driver of state-level racial inequalities in COVID-19 mortality using theoretically-informed, innovative approaches.MethodsCDC data are used to measure cumulative COVID-19 death rates between January hydrangea red sensatio
The Web runs at risk.Our generation has witnessed a tokidoki hello kitty blind box revolution in human communications on a trajectory similar to that of the origins of the written word and language itself.Early Web pages have an historical importance comparable with prehistoric cave paintings or proto-historic pressed clay ciphers.They are just as